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arcyriaflavin a, 118458-54-1, 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, CHEMBL268368, arcyriaflavin-a, BDBM2672, SCHEMBL8124103, CHEBI:93276, DTXSID50416132, GLXC-04853, HMS3229B05, HMS3269E19, HMS3413O10, HMS3677O10, BCP24907, LSM-3627, MFCD03452662, AKOS024457112, NCGC00159573-01, NCGC00159573-02, DB-081253, HY-103382, CS-0027783, FT-0701521, G13211, J-003757, BRD-K72726508-001-01-3, Q27164989, 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5 ,7(6H)-dione, 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-, 6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, 3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione, 3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione

No.	Title	Href
1	Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells. Molecules. 2022 Nov 17;27(22):7968. doi: 10.3390/molecules27227968.	`Click`

No.

Title

Href

Synergistic Anticancer Effect of a Combination of Berbamine and Arcyriaflavin A against Glioblastoma Stem-like Cells. Molecules. 2022 Nov 17;27(22):7968. doi: 10.3390/molecules27227968.

Click

Name	Arcyriaflavin A
PubChem CID	5327723
Molecular Weight	325.3g/mol
Synonyms	arcyriaflavin a, 118458-54-1, 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, CHEMBL268368, arcyriaflavin-a, BDBM2672, SCHEMBL8124103, CHEBI:93276, DTXSID50416132, GLXC-04853, HMS3229B05, HMS3269E19, HMS3413O10, HMS3677O10, BCP24907, LSM-3627, MFCD03452662, AKOS024457112, NCGC00159573-01, NCGC00159573-02, DB-081253, HY-103382, CS-0027783, FT-0701521, G13211, J-003757, BRD-K72726508-001-01-3, Q27164989, 12,13-Dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5 ,7(6H)-dione, 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 12,13-dihydro-, 6,7,12,13-Tetrahydro-5,7-dioxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole, 3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaene-12,14-dione, 3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaene-12,14-dione
Drug Type	Small molecule
Formula	C₂₀H₁₁N₃O₂
SMILES	C1=CC=C2C(=C1)C3=C4C(=C5C6=CC=CC=C6NC5=C3N2)C(=O)NC4=O
InChI	1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25)
InChIKey	KAJXOWFGKYKMMZ-UHFFFAOYSA-N
CAS Number	118458-54-1
ChEMBL ID	CHEMBL268368
ChEBI ID	CHEBI:93276
Toxicity	Organism	Test Type	Route(Dose)
Structure			Download 2D MOL 3D MOL

Pair Name	Berbamine, Arcyriaflavin A
Partner Name	Berbamine
Disease Info	[ICD-11: 2A00]	Glioblastoma multiforme		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Expression	ALDH1A1	hsa216
	Down-regulation	Phosphorylation	CAMK1G	hsa57172
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CCNA2	hsa890
	Down-regulation	Expression	CCNB1	hsa891
	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CCNE1	hsa898
	Down-regulation	Expression	CDK1	hsa983
	Down-regulation	Expression	CDK2	hsa1017
	Down-regulation	Expression	CDK4	hsa1019
	Up-regulation	Expression	CDKN1A	hsa1026
	Down-regulation	Expression	ITGA6	hsa3655
	Down-regulation	Phosphorylation	MAPK1	hsa5594
	Down-regulation	Expression	NANOG	hsa79923
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	POU5F1	hsa5460
	Down-regulation	Expression	PROM1	hsa8842
	Down-regulation	Expression	SOX2	hsa6657
	Down-regulation	Phosphorylation	STAT3	hsa6774
	Up-regulation	Expression	TP53	hsa7157
In Vitro Model	U-87MG ATCC	Glioblastoma	Homo sapiens (Human)	CVCL_0022
In Vitro Model	C6	Rat malignant glioma	Rattus norvegicus (Rat)	CVCL_0194
In Vivo Model	U87MG-derived GSCs (2×10⁶ cells/egg) were mixed with ECM gel (40 μL/egg) in the absence or presence of the compounds (5 μg/egg) and placed onto the CAM (8 eggs per group).
Result	Our findings suggest that a novel combination therapy involving berbamine and ArcA could effectively eradicate glioblastoma stem-like cells.